Limited Resources Induce Bistability in Microtubule Length Regulation
نویسندگان
چکیده
منابع مشابه
Limited resources induce bistability in microtubule length regulation
Matthias Rank, ∗ Aniruddha Mitra, 3, ∗ Louis Reese, Stefan Diez, 3, † and Erwin Frey ‡ Arnold-Sommerfeld-Center for Theoretical Physics and Center for NanoScience, Ludwig-Maximilians-Universität München, Theresienstraße 37, 80333 München, Germany B CUBE – Center for Molecular Bioengineering and Center for Advancing Electronics Dresden (cfaed), Technische Universität Dresden, Arnoldstraße 18, 01...
متن کاملMicrotubule length regulation by molecular motors.
Length regulation of microtubules (MTs) is essential for many cellular processes. Molecular motors like kinesin-8, which move along MTs and also act as depolymerases, are known as key players in MT dynamics. However, the regulatory mechanisms of length control remain elusive. Here, we investigate a stochastic model accounting for the interplay between polymerization kinetics and motor-induced d...
متن کاملProject selection with limited resources in data envelopment analysis
In this paper allocating a fixed resource for producing finite projects in order to obtaining a desired level of efficiency will be discussed. Note that it is assumed that a vector of limited sources is at hand. This vector of resources can be contained human resource, budget, equipment, and facilities. In any firm there exist different suggestions from subunits for running...
متن کاملFeedback mechanism for microtubule length regulation by stathmin gradients.
We formulate and analyze a theoretical model for the regulation of microtubule (MT) polymerization dynamics by the signaling proteins Rac1 and stathmin. In cells, the MT growth rate is inhibited by cytosolic stathmin, which, in turn, is inactivated by Rac1. Growing MTs activate Rac1 at the cell edge, which closes a positive feedback loop. We investigate both tubulin sequestering and catastrophe...
متن کاملModel of Growth Cone Membrane Polarization via Microtubule Length Regulation.
We present a mathematical model of membrane polarization in growth cones. We proceed by coupling an active transport model of cytosolic proteins along a two-dimensional microtubule (MT) network with a modified Dogterom-Leibler model of MT growth. In particular, we consider a Rac1-stathmin-MT pathway in which the growth and catastrophe rates of MTs are regulated by cytosolic stathmin, while the ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Physical Review Letters
سال: 2018
ISSN: 0031-9007,1079-7114
DOI: 10.1103/physrevlett.120.148101